Análise comparativa das doses cardíacas recebidas por pacientes com câncer de mama esquerda planejadas com duas formas alternativas de delineamento do CTV da cadeia mamária interna / Comparative analysis of heart doses received by patients with left breast cancer planned with two alternative internal mamary delineation CTVs

Propósito. Com a publicação, na última década, do resultado de grandes estudos demonstrando a correlação entre a dose de radiação recebida no coração e o aumento de eventos cardíacos adverso. Nosso estudo investiga a possibilidade de reduzir a dose cardíaca de radiação sem utilizar os protocolos ideais de inspiração profunda (DIBH). Metodologia. Analisamos os parâmetros dosimétricos referentes a 43 pacientes recebidas no departamento de radioterapia da Santa Casa de Maceió tratadas com radioterapia adjuvante em mama ou plastrão esquerdos incluindo fossa e cadeia mamária interna (MI). Todas as pacientes foram submetidas a duas tomografias e planejamentos distintos, com e sem inspiração profunda (DIBH), em um protocolo simplificado adequado para a realidade do Sistema Único de Saúde (SUS). Foram analisados os efeitos dosimétricos sobre o volume alvo, o coração, o pulmão esquerdo com o DIBH simplificado e com formas alternativas de delineamento da cadeia mamária interna. Resultados. Em nosso estudo, o protocolo de DIBH simplificado demonstrou uma redução da dose média cardíaca mesmo em pacientes incluindo radiação nodal regional ampla (692 cGy vs 502 cGy - p < 0,0001). As doses médias no ventrículo esquerdo (VE) (1222 cGy vs 857 cGy ­ p < 0,0001), na artéria coronária anterior descendente (LAD) (3739 cGy vs 3345 cGy ­ p = 0,0001) e outros parâmetros como o V25% do coração (12,4% vs 7,7% - p < 0,0001) também se mostraram reduzidas. Os delineamentos alternativos da cadeia mamária interna (MI) não produziram alterações significantes nas doses cardíacas ou pulmonares. O melhor parâmetro para predizer o benefício do DIBH foi a expansibilidade do pulmão esquerdo (r = 0,6 - p < 0,0001), sendo que os pacientes com relação entre o pulmão normal e o inspirado menor que 1,3-1,4 não obtiveram benefício significativo. Doses pulmonares também tiveram melhora estatisticamente significativa com o DIBH (média 1448 cGy vs 1294 cGy ­ p < 0,0001; V20 32,6% vs 28,2% - p <0,0001; V5 48,7% vs 45,4% - p < 0,0005), Conclusão. Nosso estudo indica que um protocolo simplificado de DIBH pode ser uma alternativa para beneficiar pacientes selecionados que necessitam reduzir a dose cárdica de radiação em tratamentos e mama esquerda e drenagens regionais em serviços de radioterapia de alta demanda e recursos limitados

Purpose. In the last decade, seminars studies demonstrated the correlation between radiation doses received in the heart with the incidence of cardiac disease, such as acute coronary events. This aroused the interest in new techniques to reduce this problem. Numerous studies have already shown that Deep Inspiration Breath Hold (DIBH) may be the best option for reducing cardiac dose. However, the vast majority of these investigations were carried out in a different scenario from the one found in our reality. Our study investigated the feasibility of reducing the cardiac dose without using an ideal DIBH protocol, which are difficult to implement in services with high demand and low economic support. Methods. The dosimetric parameters of 43 patients from the radiotherapy department of Santa Casa de Maceió were analyzed. All patients were treated with adjuvant radiotherapy to the left breast, including supraclavicular fossa and internal mammary chain (IM). The patients underwent two different CT scans and planning, with and without DIBH, in a simplified protocol suitable for the reality of tour public health system (Free Breath Hold; no respiratory training; selection of only the patients with greater benefit). The dosimetric impact on the heart, its substructures and the left lung were studied with the simplified DIBH and with alternative forms of delineation to the IM. Results. The simplified DIBH protocol demonstrated, in our study, a reduction in mean cardiac dose for patients including wide regional nodal radiation (692 cGy vs 502 cGy - p < 0.0001). The doses for the Left ventricular (1222 cGy vs 857 cGy ­ p < 0.0001), the Left anterior-descending coronary (3739 cGy vs 3345 cGy ­ p = 0.0001) and other parameters such as heart V25% (12.4% vs 7, 7% - p < 0.0001) were also reduced. The doses to the heart did not achieve statistically significant reduction with alternative delineation of the MI CTV. The best parameter predicting the benefit of DIBH was the left lung expansion (r = 0.6 - p < 0.0001), with patients with a ratio lower than 1.3-1,4 having no significant benefit. Pulmonary doses also showed a statistically significant improvement with DIBH (Dmed 1448 cGy vs 1294 cGy ­ p < 0.0001; V20 32.6% vs 28.2% - p <0.0001; V5 48.7% vs 45, 4% - p < 0.0005), but the reductions were small, as was the increase in pulmonary dose when the MI CTV is outlined to joining the supraclavicular fossa. Conclusion. Our study indicates that a simplified DIBH protocol may serve as an option to benefit selected patients with locally advanced breast cancer treated in departments with high occupation of the Linacs and low capacity for investment in new technology

Transcutaneous Electrical Acupoint Stimulation Combined with Warm Acupuncture for Breast Cancer Related Upper Limb Lymphedema: A Retrospective Cohort Study / 中国结合医学杂志

OBJECTIVE@#To observe the clinical efficacy of transcutaneous electrical acupoint stimulation (TEAS) combined with warm acupuncture in treating breast cancer associated with upper limb lymphedema (BCRL).@*METHODS@#This was a retrospective cohort study using a paired control design. Fifty-two BCRL patients were assigned to the control group (27 cases) and the treatment group (25 cases). The patients in the control group were treated with lymphedema comprehensive detumescence treatment (CDT) for 4 weeks, including systematic therapy composed of manual lymphatic drainage, compression bandage, skincare, and functional exercise. The patients in the treatment group were treated with TEAS combined with warm acupuncture based on the control group methods. Each treatment lasted for 30 min and was applied twice a week for 4 weeks. The arm circumference (AC) of different positions of the affected limb and the degree of swelling of the affected limb were evaluated before the first treatment and after the last treatment. The clinical efficacy was evaluated according to the degree of edema before and after treatment. All adverse events during treatment were recorded.@*RESULTS@#The patients' AC and the swelling feeling of the affected limb in the treatment group and the control group were both reduced compared with those before treatment. Compared with the control group, AC of the wrist joint transverse stria, the midpoint between the wrist joint transverse stria and the elbow joint transverse stria in the treatment group were significantly reduced (P<0.05). The decrease in AC diameter at the midpoint between the elbow joint transverse stria and the axillary transverse stria was the most significant (P<0.01). The swelling degree of the affected limbs in the treatment group was significantly lower than before treatment, and was significantly lower compared with the control group after treatment (P<0.01). The total effective rate was 72% in the treatment group, significantly higher than that in the control group (55.56%, P<0.05). No serious adverse events occured in either group.@*CONCLUSIONS@#TEAS combined with warm acupuncture can effectively reduce AC and swelling feeling of the affected limb in patients with BCRL. The effect is better than that of CDT therapy alone. (Registration No. ChiCTR2200062075).

Frequência e fatores associados ao atraso para o tratamento do câncer de mama no Brasil, segundo dados do PAINEL-Oncologia, 2019-2020 / Frecuencia y factores asociados al retraso en el tratamiento del cáncer de mama en Brasil, según datos del Panel de Oncología, 2019-2020 / Frequency and factors associated with delay in breast cancer treatment in Brazil, according to data from the Oncology Panel, 2019-2020

Objective: to analyze treatment delay and the flow of care for women with breast cancer in Brazil in 2019 and 2020. Method: this was a follow-up study of breast cancer cases available from the Oncology Panel; a chi-square test and multilevel logistic regression were performed in order to analyze the explanatory variables associated with delay (greater than 60 days) in starting treatment. Results: 22,956 cases (54.5%) with delay in treatment were identified in 2019 and 17,722 (48.7%) in 2020; the Southeast region (54.6%) had the greatest proportion of delay; delay was greater when treatment was provided outside the municipality of residence and lower in 2020 compared to 2019; most outward flows were to the capital cities in the same Federative Units of residence. Conclusion: strategies to reduce cancer treatment delay and optimize health care networks in the Federative Units should be prioritized.

Resumen Objetivo: analizar la demora en el tratamiento y el flujo asistencial de mujeres con cáncer de mama en Brasil en 2019 y 2020. Método: estudio de seguimiento de los casos de cáncer de mama disponibles en el Panel de Oncología. Para analizar las variables explicativas asociadas al retraso (mayor de 60 días) en el inicio del tratamiento se realizó la prueba de chi-cuadrado y la regresión logística multinivel. Resultados: se identificaron 22.956 casos (54,5%) en 2019 y 17.722 (48,7%) en 2020 con retraso en el tratamiento. La región Sudeste (54,6%) tuvo mayor proporción de atraso, siendo mayor cuando se realizó fuera del municipio de residencia y menor en 2020 en relación a 2019. Los flujos externos, en su mayoría, ocurrieron en las capitales de las mismas Unidades de la Federación (UFs) de residencia. Conclusión: se deben priorizar estrategias que reduzcan el intervalo de tiempo hasta el inicio del tratamiento del cáncer y optimicen las redes de atención de salud en los estados.

Objetivo: analisar o atraso para o tratamento e o fluxo assistencial de mulheres com câncer de mama no Brasil em 2019 e 2020. Métodos: estudo de seguimento de casos de câncer de mama disponibilizados no PAINEL-Oncologia; para analisar as variáveis explicativas associadas ao atraso (maior que 60 dias) no início do tratamento, realizou-se teste qui-quadrado e regressão logística multinível. Resultados: identificaram-se 22.956 casos (54,5%) em 2019 e 17.722 (48,7%) em 2020, com atraso para o tratamento; a região Sudeste (54,6%) teve maior proporção de atraso, que foi maior quando o tratamento foi realizado fora do município de residência, e menor em 2020, comparando-se a 2019; os fluxos externos, em sua maioria, ocorreram para as capitais das mesmas Unidades da Federação (UFs) de residência. Conclusão: estratégias que diminuam o intervalo de tempo até o início do tratamento oncológico e otimizem as redes de atenção em saúde nas UFs devem ser priorizadas.

Sequels associated with breast cancer treatment: what is important to measure in a report

Breast cancer treatment is associated with functional sequelae that limit patients in their daily activities or work, impacting their quality of life. This fact becomes more noticeable in the Public System, the tumors are more advanced, leading to more aggressive treatments. Women with low education generally perform menial activities, playing an important role in family income. After cancer treatment, many are unable to carry out their usual activities, having difficulties with their work activities, requiring rehabilitation. These dysfunctions make it difficult or unfeasible to return to work, limiting family income. Knowledge of the Laws, the main sequelae and evaluation methodologies facilitates a more accurate diagnosis of functional conditions, determining the need for rehabilitation. Social Security provides economic support, but to have access to the benefit, a good report is necessary. This, well directed, helps the social security expert and the patients, who are generally so fragile by the disease and the treatment. In this article we discuss the main functional sequelae, how to evaluate them, and how to make a good report to be sent to an expert (AU)

Breast cancer and covid-19: reduction in diagnosis and treatment in a Hospital Unit in Pernambuco / Câncer de mama e covid-19: redução no diagnóstico e tratamento em uma Unidade Hospitalar de Pernambuco

Abstract Objectives: to analyze the impact of the covid-19 pandemic on screening, diagnosis and treatment of breast cancer in Pernambuco, Northeastern Brazil. Method: cross-sectional study, based on secondary data from consultations with a mastologist, ultrasound, mammogram, biopsies, new cases, chemotherapy, radiotherapy and surgery, carried out in women for the screening, diagnosis and treatment of breast cancer, from January to December of the years 2019 to 2021. Results: the covid-19 pandemic reduced consultations with mastology (46.3%), ultrasounds (34.8%), mammogram (41.5%), biopsy (49.6%), new cases 45.7 % and surgery 34.6% in 2020 compared to 2019. On the other hand, with the exception of consultations with a mastologist and surgeries, all services where a significant reduction was observed in 2020, increased significantly in 2021 and returned to the same level of production in the pre-pandemic period. The pandemic did not negatively affect the supply of chemotherapy and radiotherapy. Conclusions: the findings of this study indicate negative impacts on breast cancer care, due to covid-19, during the first year of the pandemic, especially in consultations with a mastologist and surgery, which continued with low production in 2021. It is reasonable to assume that the reduction observed in procedures may reflect an increase in late diagnoses and a higher mortality rate in the coming years

Resumo Objetivos: analisar o impacto da pandemia da covid-19 nos atendimentos para rastreamento, diagnóstico e tratamento do câncer de mama em Pernambuco, Nordeste do Brasil. Métodos: estudo transversal, com base em dados secundários de consultas com mastologista, ultrassonografia, mamografia, biópsias, casos novos, quimioterapia, radioterapia e cirurgia, realizadas em mulheres para o rastreamento, diagnóstico e tratamento do câncer de mama, de janeiro a dezembro dos anos 2019 a 2021. Resultados: a pandemia da covid-19 reduziu as consultas com a mastologia (46,3%), ultrassonografias (34,8%), mamografia (41,5%), biópsia (49,6%), casos novos 45,7% e cirurgia 34,6% no ano de 2020 em relação ao ano de 2019. Por outro lado, com exceção das consultas com mastologista e cirurgias, todos os serviços onde se observou redução significativa em 2020, aumentaram significativamente em 2021 e voltaram ao patamar de produção do período pré-pandemia. A pandemia não afetou negativamente a oferta de quimioterapia e radioterapia. Conclusões: os achados deste estudo apontam impactos negativos na atenção ao câncer de mama, em decorrência da covid-19, durante o primeiro ano da pandemia, sobretudo nas consultas com mastologista e cirurgia, que continuaram com baixa produção em 2021. É razoável supor que a redução constatada nos procedimentos poderá refletir em um aumento de diagnósticos tardios e maior taxa de mortalidades nos próximos anos.

Asociación de colgajo dorsal ancho pediculado y libre para reconstrucción de grandes defectos de mama y tórax / Association of pedicled and free latissimus dorsi flap for reconstruction of large breast and thoracic defects

Introducción. Los tratamientos del cáncer de mama en estadios avanzados suelen ser tratamientos radicales. Ello implica la resección de grandes cantidades de tejido, a veces asociada a radioterapia o a procedimientos como quimioembolización intraarterial, lo que suele dar como resultado un gran defecto de cobertura cutánea que involucra no solo la mama sino también todo el hemitórax. Esto resulta un desafío para el cirujano plástico reconstructivo, ya que tiene que acudir a técnicas reconstructivas más complejas. En este trabajo proponemos, para estas pacientes, reconstrucción mamaria unilateral con la utilización de dos colgajos para cubrir el defecto completamente y así restaurar el tórax y la mama. Pacientes y métodos. Se realiza un estudio retrospectivo desde enero de 2017 a agosto de 2019. Se analizan 11 (once) pacientes con grandes defectos de cobertura cutánea. Diez pacientes reúnen la característica común de haber presentado cáncer de mama en estadio III, sometiéndose a cirugía radical + radioterapia. Una de las once presenta una necrosis extensa del hemitórax y la mama producto de una complicación de la quimioembolización intraarterial. Se realizó reconstrucción mamaria unilateral en dos tiempos con tejido autólogo mediante dos colgajos: colgajo dorsal ancho pediculado + colgajo dorsal ancho libre (6 casos). Una de ellas acude con el primer colgajo dorsal ancho pediculado realizado en otra institución; colgajo dorsal ancho pediculado + colgajo DIEP (3 casos); colgajo dorsal ancho pediculado + colgajo SGAP (1 caso), colgajo TRAM pediculado y colgajo dorsal ancho pediculado (1 caso). Resultados. Todos los colgajos sobrevivieron. El caso del paciente con colgajo TRAM fue derivado de otra institución con una vitalidad del 50%. Se presentó un caso de seroma en zona dadora de la espalda y una dehiscencia de herida en el mismo. El seguimiento promedio fue de 21,36 meses luego de la segunda instancia quirúrgica. Conclusiones. Los grandes defectos de tejidos blandos en el tórax anterior causados por resecciones extrarradicales de mama dejan defectos demasiado grandes para ser cubiertos por los colgajos de reconstrucción mamaria tradicionales. La reconstrucción mediante la asociación de un colgajo dorsal ancho pediculado y un colgajo dorsal ancho libre demostró ser una buena opción estética y funcional para poder resolver estos casos complejos que involucran no solo a la mama, sino también a la región torácica.

Large soft tissue defects in the anterior thorax cause by extraradical breast resections leave too large defects to be covered by traditional breast reconstruction flaps. Reconstruction by association of a pedicled latissimus dorsi flap and a free latissimus dorsi flap proved to be a good aesthetic and functional option, so much to be able to solve these complex cases that involve not only the breast as well also to the thoracic region.

Costos médicos directos de la atención médica de pacientes con cáncer de mama / Direct medical costs in a cohort of patients with breast cancer

Introducción: el costo económico del tratamiento de cáncer de mama (CM) y el aumento en su incidencia y prevalencia desafía la estabilidad financiera de cualquier sistema de salud. Objetivo: determinar los costos médicos directos (CMD) del tratamiento de CM y los factores asociados a estos costos. Material y métodos: evaluación económica parcial en una cohorte retrospectiva de 160 pacientes con diagnóstico conf irmado de CM. Se consideraron CMD desde la perspectiva del IMSS. Se utilizó análisis de bootstrapping para tratar incertidumbre y el modelo lineal generalizado para identificar factores asociados a costos. Resultados: el costo promedio anual (CPA) del tratamiento de CM fue de $ 251,018 pesos. En estadio 1, $ 116,123; estadio II, $ 242,132; estadio III, $ 287,946, y estadio IV, $ 358,792 pesos. El CPA fue mayor en progresión del CM ($ 380,117 frente a no progresión $ 172,897), y en pacientes que fallecieron durante el seguimiento ($ 357,579) frente a aquellas que sobrevivieron ($ 218,699). Conclusiones: el CPA del tratamiento de CM fue de $ 251,018 pesos. Los CMD aumentan significativamente conforme las pacientes presentan estadios más avanzados de la enfermedad. Los factores asociados al CMD fueron edad, estadios II, III y la progresión del CM.

Background: The economic cost of breast cancer (BC) treatment and the increase in incidence and prevalence challenges the financial stability of any healthcare system. Objective: To determine direct medical costs (DMC) of BC treatment and factors associated with DMC. Material and methods: Partial economic evaluation in a retrospective cohort of 160 patients with a confirmed diagnosis of BC. DMC was considered from the IMSS perspective. Bootstrapping analysis was used to deal with uncertainty and generalized linear model to identify factors associated with DCM Results: The total average annual cost of BC treatment was $251,018 mexican pesos. In clinical stage I was $116,123, stage II $242,132, stage III $287,946, and stage IV $358,792 pesos. In progression disease, DMC were more elevate ($380,117) vs. without progression ($172,897), (p < 0.0001). In patients who died, DMC were $357,579 mexican pesos compared to those who survived ($218,699) (p < 0.0001). Conclusions: The average annual cost of CM treatment was $251,018 pesos. DMCs increase significantly as patients present more advanced stages of the disease. Factors associated with costs were age, stages II, III and the progression of BC.

Effect of ribociclib on productivity losses due to breast cancer in young women in Brazil

ABSTRACT OBJETIVE To evaluate the effect of ribociclib versus endocrine therapy on productivity losses due to advanced breast cancer. METHODS Productivity data from the MONALEESA-7 trial, obtained from the results of the application of the Work Productivity and Activity Impairment (WPAI) questionnaire on progression-free survival state (43-month follow-up), were extrapolated to the 10,936 Brazilian prevalent cases of premenopausal women with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer. Productivity loss was determined by quantifying the economic costs of workforce dropout over time in both treatment arms and by discounting the economic costs of absenteeism and presenteeism from workforce retention. A human capital approach was used. RESULTS Net productivity gains in the ribociclib arm were estimated at USD 4,285,525.00, representing 316,609 added work hours over 43 months and a mean of 2,009 added work weeks per year. CONCLUSIONS The phase III MONALEESA-7 trial productivity results applied to the Brazilian premenopausal prevalent cases of hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer showed that treatment with ribociclib + endocrine therapy improves workforce participation compared with endocrine therapy alone in premenopausal women with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer, with potential economic gains for the Brazilian society.

Comprehensive management guideline for breast cancer follow-up and healthcare (2022 edition) / 中华肿瘤杂志

In recent years, with the emphasis on breast cancer screening and the improvement of standardized diagnosis and treatment, cure rate and survival time of breast cancer patients have been significantly improved in China. Accompanied by prolonged follow-up period, patients are facing increasing cancer and other related health issues, which calls for a more accurate and long-term follow-up plan and focus on broader health risks. Health issues on cardiovascular system, bone density, blood lipid and psychology caused by anti-cancer treatment, senescence or changes in hormone levels have become new challenges in the management of patients with breast cancer, not only affecting the life quality, but also impacting disease recurrence and death. Therefore, in addition to standardized treatment, scientific and standardized follow-up, comprehensive management of patients' concomitant diseases, interdisciplinary cooperation and holistic rehabilitation are also vital links to treatment. This could improve the therapeutic efficacy of anti-cancer treatment and the quality of life of patients. Based on the current landscape of treatment and follow-up of breast cancer patients in China, the experts committee updated the "Comprehensive Management Guideline for Breast Cancer Follow-up and Concomitant Diseases (2019 edition)" and revised it as "Guidelines for breast cancer follow-up and health management in China (2022 edition)" according to the latest literature and guidelines and medical advice from interdisciplinary experts. This new guideline is composed of four parts: path diagram, follow-up management, comprehensive healthcare management, and patient reported outcome. It aims to standardize the long-term follow-up of breast cancer patients, guide clinicians to actively provide comprehensive interdisciplinary healthcare management, and further improve the prognosis and life quality of breast cancer patients in China.

Is paclitaxel less cardiotoxic in the treatment of breast cancer before or after doxorubicin? / Qual estratégia terapêutica é menos cardiotóxica no tratamento do câncer de mama: uso de paclitaxel antes ou depois da doxorrubicina?

Background: The combination of doxorubicin (DOX) with paclitaxel (PTX) effectively treats breast cancer (BC). However, DOX-associated cardiotoxicity (CTX) is aggravated by the use of PTX. Consensus is lacking about which drug sequence involves the most CTX. Objectives: To evaluate whether DOX followed by PXT or the reverse sequence has the greatest cardiotoxic potential in the treatment of BC. Methods: Prospective study of women with primary BC who received four cycles of DOX and 12 infusions of PTX. Participants were divided into Group 1 (G1; PXT before DOX) and Group 2 (G2; DOX before PXT) at the discretion of the oncologist. CTX was defined as an absolute reduction in left ventricular ejection fraction (LVEF) > 10% to a value <53%. Patients underwentclinical evaluations and echocardiography before treatment (Phase 1) and one year after treatment (Phase 2). Results: Sixty-nine women were evaluated: 19 in G1 and 50 in G2. The groups had similar clinical characteristics. The doses of radiation, DOX, and PTX used were similar. Eight (11.6%) patients developed CTX: two (10.5%) in G1 and six (12.0%) in G2 (p=0.62). The mean LVEF was similar between groups in Phase 1 (G1=65.1±3.5%; G2=65.2±3.9%; p=0.96), with a significant reduction noted after one year in both groups: G1=61.4±8.1% (p=0.021) and G2=60.8±7.6% (p<0,001). Although lower, mean LVEF remained similar between groups after Phase 2 (p=0.79). Conclusions: In women with BC who underwent chemotherapy, the incidence of CTX at the end of the first year of treatment was similar regardless of whether DOX was used before or after PTX. (AU)

Atenção ao câncer de mama a partir da suspeita na atenção primária à saúde nos municípios de São Paulo e Campinas, Brasil / Breast cancer care from a suspected case detected in primary health care in São Paulo and Campinas, Brazil

Resumo Buscou-se identificar fatores que interferem na suspeita do câncer de mama (CM) pela atenção primária à saúde (APS) que impulsionam o encaminhamento para a atenção especializada (AE) nos municípios de São Paulo e Campinas. Foram entrevistadas 664 mulheres (353 paulistanas e 311 campineiras) diagnosticadas com CM, encaminhadas para AE pela APS. Utilizou-se a análise de regressão logística multinível para a identificação das associações entre a suspeita do CM pela APS, variáveis socioeconômicas e atenção ao câncer. Mostraram associação significativa: nível superior de escolaridade (RC = 0,59; IC 95% = 0,35-0,98); pagamento de consulta médica para atendimento relacionado ao câncer (RC = 0,59; IC 95% = 0,36-0,96), continuou atendimento na APS após início do tratamento na AE (RC = 0,62; IC 95% = 0,41-0,95); mama examinada na APS (ECM) antes do encaminhamento para a AE (RC = 1,61; IC 95% = 1,10-2,34) e primeira mamografia solicitada na APS (RC = 2,81; IC 95% = 1,95-4,00). A solicitação da mamografia e o ECM são ações que têm sido incorporadas na APS para a detecção precoce do CM nos municípios. Continuar o atendimento na APS e melhores condições socioeconômicas, como ter nível superior de escolaridade e capacidade de pagar por atendimento, reduzem a chance da suspeita.

Abstract We aimed to identify factors that interfere in breast cancer (BC) suspected cases detected in Primary Health Care (PHC) that drive the referral to Specialized Care (SC) São Paulo and Campinas, Brazil. We interviewed 664 women (353 from São Paulo and 311 from Campinas) diagnosed with BC, referred to SC from PHC. Multilevel logistic regression analysis was used to the identification of associations between BC suspected cases by PHC and the socioeconomic and cancer care variables. The following showed a significant association: higher schooling level (OR = 0.59; 95% CI = 0.35-0.98); medical visit payment for cancer-related care (OR = 0.59; 95% CI = 0.36-0.96), continued attendance at PHC after beginning treatment at SC (OR = 0.62; 95% CI = 0.41-0.95); breast examined in PHC before referral to SC (OR = 1.61; 95% CI = 1.10-2.34) and first mammography requested in PHC (ECM) (OR = 2.81; 95% CI = 1.95-4.00). The request for mammography and the clinical breast examination is incorporated into the PHC for the early detection of BC in the cities. Continuing the care at the PHC and better socioeconomic conditions, such as having a higher education level and capacity to pay for care, can reduce the likelihood of suspected cases.

Teleoncology Orientation of Low-Income Breast Cancer Patients during the COVID-19 Pandemic: Feasibility and Patient Satisfaction / Orientação teleoncológica de pacientes de baixa renda com câncer de mama durante a pandemia de COVID-19: Viabilidade e satisfação do paciente

Abstract Objective The present study aims to assess the feasibility and patient satisfaction of teleoncology orientation in a vulnerable population of breast cancer patients assessed in a government health system during the coronavirus pandemic in 2020. Methods Eligible patients received an invitation to receive remote care to minimize exposure to an environment in which the risk of respiratory infection was present. The means of communication was telephone through an application that allows free conversation with no charge. An anonymous-response questionnaire based on a Likert-type scale was sent through a cell phone application or e-mail directly to each patient or close relative of the patient immediately after teleconsultation. Responses to the questions, which addressed utility, facility, interface quality, interaction quality, reliability, satisfaction, and interest in future evaluation, were compiled and analyzed. Results A total of 176 eligible patients scheduled for consultation were evaluated and 98 were included. Seventy (71.4%) successfully undertook the teleorientation. The questionnaire was submitted by 43 (61.4%) patients. The overall teleoncology orientation was classified as very positive by 41 (95.3%) patients. Specifically, regarding the questionnaire items, 43 (100%) patients scored 4 or 5 (agreed that the teleconsultation was beneficial) concerning the facility, followed by 42 (97.2%) for the interface quality, 41 (95.3%) for both utility and interaction quality, 40 (93%) for satisfaction and interest in future evaluation, and, finally, 39 (90.6%) for reliability. Conclusion Teleoncology orientation of low-income breast cancer patients is most feasible and leads to high patient satisfaction.

Resumo Objetivo O presente estudo teve como objetivo avaliar a viabilidade e satisfação em relação à orientação teleoncológica realizada em população vulnerável de pacientes com câncer de mama e provenientes do sistema público de saúde durante a pandemia do coronavírus em 2020. Métodos Pacientes elegíveis foram agendados para atendimento remoto visando minimizar exposição a ambientes com risco de infecção respiratória. O meio de comunicação foi o telefone, pois permite conversa sem custos. Um questionário anônimo com base na escala Likert foi enviado através de aplicativo de telefone celular ou e-mail para paciente ou familiares, logo após a teleconsulta. As respostas, que abordavam utilidade, facilidade, qualidade da interface, qualidade da interação, confiabilidade, satisfação e interesse em avaliações futuras, foram compiladas e analisadas. Resultados Um total de 176 pacientes elegíveis para teleconsulta foram avaliados e 98 foram incluídos. Setenta (71,4%) realizaram a teleorientação com sucesso. O questionário foi respondido por 43 (61,4%) pacientes. De maneira geral, a teleorientação foi classificada como muito positiva por 41 (95,3%) pacientes. Em relação aos itens avaliados, 43 (100%) pacientes pontuaram 4 ou 5 (concordaram que a teleconsulta era benéfica) em relação à facilidade do serviço, seguido por 42 (97,2%) para a qualidade da interface, 41 (95,3%) tanto para a utilidade quanto para a qualidade da interação, 40 (93%) para satisfação e interesse em avaliação futura e 39 (90,6%) para confiabilidade em relação ao método. Conclusão A orientação teleoncológica empacientes de baixa renda e com câncer de mama mostrou ser viável e com altas taxas de satisfação.

The efficiency of a mixed exercise program on quality of life and fatigue levels in patients with breast cancer

SUMMARY OBJECTIVE: Exercise is a nonpharmacological supportive therapy which has been specifically identified to reduce postoperative complications or adverse events of cancer or treatments. Although there are few studies combining resistance and aerobic exercise in cancer survivors, exercise programs are very rare in different places in the literature. This study aims to investigate the effects of mixed-type exercise in different venues on weight, body mass index, fatigue, and quality of life in cancer survivors. METHODS: This is a descriptive, intervention study. Participants were included in the study, and the exercise process was between January and November 2019. The exercise group consisted of 32 patients who had just completed their breast cancer treatment and did not have distant metastases, and they applied a mixed exercise program including resistance at home and aerobic exercise in the fitness center for 12 weeks. The patients with breast cancer in the control group (30 patients) did not receive any exercise program. RESULTS: Subjective feelings of fatigue and decrease in concentration, motivation, and physical activity significantly decreased after exercise (p<0.001, p<0.001, p=0.006, p=0.008, and p<0.001, respectively) in the study group. The results also showed that physical health, general health status, and emotional and social health status significantly increased with the exercise program (p<0.001, p<0.001, p=0.004, and p=0.003, respectively). CONCLUSION: Our results show that a mixed (fitness center and home) 12-week exercise program provides an improvement in general health and reduces the side effects of the treatments and fatigue in patients with breast cancer. For a good prognostic process after medical treatment, exercise can be recommended in every accessible area.

Impact of home-based aerobic training combined with food orientation on food consumption, daily physical activity and cardiorespiratory fitness among breast cancer survivors: six-month clinical trial

ABSTRACT BACKGROUND: Anticancer treatment gives rise to adverse effects such as increased pain and changes to body weight and menstrual cycles, with negative effects on activities of daily living. OBJECTIVE: To analyze the effect of food orientation combined with supervised (face-to-face, FF) versus home-based (HB) aerobic training on lifestyle (food consumption and daily physical activity (PA) levels), body composition, metabolic profile and cardiorespiratory fitness, among breast cancer survivors. DESIGN AND SETTING: Clinical trial study (six months) conducted at a public university in Presidente Prudente, Brazil. METHODS: Twenty-three female breast cancer survivors (40-75 years old) were allocated to aerobic training groups, either FF or HB. Both groups were trained and received food orientation. They were evaluated through a dietary record, ergometric treadmill test and blood test and the Baecke questionnaire. RESULTS: After six months, both groups had reduced their lipid levels, total energy consumption and polyunsaturated fat intake, and had increased their PA levels and treadmill test durations. However, only the HB showed reduced carbohydrate percentage and increased folic acid; and only the FF showed reduced lipid, saturated fat and sodium levels, along with increased carbohydrate and protein levels. No differences in body composition or metabolic profile were found. CONCLUSIONS: These results demonstrated the feasibility of HB aerobic training. In isolation, HB showed greater regulation of carbohydrate percentage and increased folic acid levels. Moreover, these breast cancer survivors presented improvements in food consumption, PA levels and cardiorespiratory fitness, while also maintaining their body composition and metabolic profile after the intervention, independent of the group.

Caracterización del cáncer de mama de un servicio de salud pública del sur de Chile según edad, período 2005-2015 / Characterization of breast cancer of a public health service in southern Chile according to age, period 2005-2015

INTRODUCCIÓN: En Chile ha aumentado la morbilidad y mortalidad por el cáncer de mama (CaMa), y el Servicio de Salud de Talcahuano (SST) ha realizado acciones para pesquisarlo precozmente y cumplir con las garantías explícitas en salud (GES) OBJETIVO: Caracterizar los ingresos por CaMa del SST en el período 2005-2015. MÉTODO: Estudio transversal de 1.077 mujeres diagnosticadas con CaMa en la Unidad de Patología Mamaria (UPM) del SST. Variables: edad, tipo histológico, etapificación, tratamiento y cumplimiento de las GES. Análisis univariado y bivariado con suite estadística SPSS v25. RESULTADOS: Los casos aumentaron en todo el período de estudio, excepto en 2011. Concentrando el 35,5% en mujeres de ≥65 años. El carcinoma ductal invasor ascendió al 73,5% de los tipos histológicos, y 41,9% tenía un tamaño tumoral entre 2 y 5 cms. Las mujeres de 65 y más años presentan los porcentajes más altos en frecuencia y tamaño de tumor. El 78,6% ingresó en etapa 0 a IIB. Los tratamientos más frecuentes fueron: hormonoterapia (81,4%), radioterapia (80,1%), mastectomía parcial (69,4%), quimioterapia (56,3%) y disección axilar (55,7%). El cumplimiento de las garantías GES, es mayor en la confirmación diagnóstica (87%) que en el inicio de tratamiento (77,3%). CONCLUSIÓN: Ascendió sostenidamente el CaMa en el SST, excepto en 2011, quizás condicionado por el terremoto del año 2010. La mayoría de los ingresos lo hacen en etapas tempranas, en mujeres ≥50 años (especialmente en ≥65 más) y con tratamientos más conservadores. Existe un alto cumplimiento de las GES del CaMa en el SST.

INTRODUCTION: Breast cancer morbidity and mortality has increased in Chile, and the Talcahuano Health Service (THS) has taken measures for an early detection and complying with the country's Explicit Health Guarantees program (GES in Spanish). OBJECTIVE: To characterize admissions to the THS for breast cancer between 2005 and 2015. Methods: Cross-sectional study, consisting of 1077 women who had been diagnosed with breast cancer in the Mammary Pathologies Unit of the THS. Variables: age, histological type, staging, treatment, and GES compliance. Univariate and bivariate analysis, using SPSS v25. RESULTS: Cases increased every year but on 2011, with 35.5% of them being women aged 65 or older. Invasive ductal carcinoma accounted for 73.5% of the histological types, while 41.9% presented a tumor size of 2-5 cm. Women aged 65 and older showed the highest percentages in frequency and tumor size. 78.6% of cases were admitted while on stages 0 to IIB. Most frequent treatments were hormone therapy (81.4%), radiotherapy (80.1%), partial mastectomy (69.4%), chemotherapy (56.3%), and axillary dissection (55.7%). GES compliance was higher in the diagnosis stage (87.0%) than at the start of treatment (77.3%). CONCLUSION: Breast cancer rates have steadily increased in the THS but on 2011, which could be due to the 2010 Chile earthquake. Most admissions are women aged 50 or more (especially ≥ 65), on early stages, and under more traditional treatments. There is a high rate of GES compliance in this health service.

Tratuzumab subcutáneo en el tratamiento cáncer de mama HER2 positivo / Subcutaneous Tratuzumab in the Treatment of HER2 Positive Breast Cancer

El presente informe es producto del trabajo colaborativo de la Comisión Nacional de Evaluación de Tecnologías de Salud (CONETEC), dependiente del Ministerio de Salud de la Nación y creada por RM N° 623/2018. La CONETEC realiza evaluaciones y emite recomendaciones a la autoridad sanitaria sobre la incorporación, forma de uso, financiamiento y políticas de cobertura de las tecnologías sanitarias desde una perspectiva global del sistema de salud argentino. En sus evaluaciones y recomendaciones, la CONETEC tiene en cuenta criterios de calidad, seguridad, efectividad, eficiencia y equidad, evaluados bajo dimensiones éticas, médicas, económicas y sociales. Sus resultados son consensuados mediante discusiones públicas y ponderados a través de un marco de valor explícito, con la participación de todos los actores involucrados en el proceso de toma de decisiones en salud. Los informes y recomendaciones de esta comisión surgen de este proceso público, transparente y colaborativo, siendo de libre consulta y acceso para toda la sociedad.

Physical Functionality of the Upper Limb after Breast Cancer Surgery in Southern Brazilian Survivors: Cross-Sectional Study / Funcionalidade do Membro Superior após a Cirurgia do Câncer de Mama em Sobreviventes do Sul do Brasil: Estudo de Corte Transversal / Función Física de la Extremidad Superior Después de una Cirugía de Cáncer de Mama en Sobrevivientes del Sur de Brasil: Estudio Transversal

Introduction: Surgical treatment after the diagnosis of breast cancer can lead to several consequences of the survivor's upper limb. Objective: Analyze the physical function of the upper limb after breast cancer surgery in Southern Brazilian survivors. Method: 82 breast cancer survivors (55±10 years) receiving hormone therapy were included. A questionnaire for general information, pain (Visual Analogue Scale), and upper limb functionality (DASH) were applied, followed by physical tests; the shoulder range of motion (goniometer), strength (dynamometer), proprioception (kinesimeter) and arm volume (perimeter of the arm). Results: No differences were found for any variable of physical function in relation to mastectomy or breast-conserving surgery. However, better scores of strength and the shoulder range of motion were found for the non-surgery arm. Linear regression demonstrated a relation between pain, strength, range of motion, proprioception, and arm volume with the disabilities of the upper limb, and when adjusted by surgery modality, shoulder range of motion, arm volume, and proprioception maintained significantly. Conclusion: Breast cancer survivors presented physical disabilities on the upper limb after surgery, regardless of the modality of surgery. Results elucidate the need for an efficient post-treatment program to prevent poor physical function after breast cancer surgery and provide better daily activities to these women.

Introdução: O tratamento cirúrgicodo câncer de mama pode levar a consequências físicas no membro superior de sobreviventes. Objetivo: Analisar a funcionalidade do membro superior após cirurgia de câncer de mama em sobreviventes do Sul do Brasil. Método: Foram avaliadas82 sobreviventes de câncer de mama (55±10 anos) em tratamento com hormonioterapia. Foi aplicado um questionário para informações gerais, dor (Escala Visual Analógica) e funcionalidade do membro superior (DASH), seguido de testes físicos; amplitude de movimento (goniômetro), força (dinamômetro), propriocepção (cinesiômetro) e volume do braço (perímetro do braço). Resultados: Não foram encontradas diferenças para nenhuma das variáveis de funcionalidade em relação à mastectomia ou cirurgia conservadora de mama. No entanto, melhores escores de força e amplitude de movimento foram apresentados no membro contralateral à cirurgia. A regressão linear demonstrou uma relação entre dor, força, amplitude de movimento, propriocepção e volume do braço com as disfunções do membro superior e, quando ajustada pela modalidade de cirurgia, apenas a amplitude de movimento, volume do braço e propriocepção mantiveram--se significativamente. Conclusão: A cirurgia do câncer de mama pode levar à pior funcionalidade no membro superior, independentemente da modalidade da cirurgia. Os resultados elucidam a necessidade de um programa eficiente de pós-tratamento para prevenir as consequências na função física do membro superior após cirurgia de câncer de mama e proporcionar melhora nas atividades de vida diária nessa população.

Introducción: El tratamiento quirúrgico después del diagnóstico de cáncer de seno puede conducir a varias consecuencias de la extremidad superior de la sobreviviente. Objetivo: Analizar la función física de la extremidad superior después de una cirugía de cáncer de mama en sobrevivientes del sur de Brasil.Método: Se incluyeron 82 sobrevivientes de cáncer de mama (55±10 años) que recibieron terapia hormonal. Se aplicó un cuestionario para información general, dolor (escala analógica visual) y funcionalidad de la extremidad superior (DASH), seguido de pruebas físicas; el rango de movimiento (goniómetro), fuerza (dinamómetro), propiocepción (kinesímetro) y volumen del brazo (perímetro del brazo). Resultados: No se encontraron diferencias para ninguna variable de la función física con respecto a someterse a una mastectomía o cirugía conservadora de seno. Sin embargo, se encontraron mejores puntajes de fuerza y rango de movimiento para el brazo no quirúrgico. La regresión lineal demostró una relación entre el dolor, la fuerza, el rango de movimiento, la propiocepción y el volumen del brazo con las discapacidades de la extremidad superior, y cuando se ajustó por la modalidad quirúrgica, el rango de movimiento, el volumen del brazo y la propiocepción se mantuvieron significativamente. Conclusión: Las sobrevivientes de cáncer de mama presentaron discapacidades físicas en la extremidad superior después de la cirugía, independientemente de la modalidad de la cirugía. Los resultados aclaran la necesidad de un programa de postratamiento eficiente para prevenir la mala función física después de la cirugía de cáncer de mama y proporcionar mejores actividades diarias a estas mujeres.